Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional) | PAS 25 190

Opportunity Information: Apply for PAS 25 190

The NIH funding opportunity "Research Opportunities for New and 'At-Risk' Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)" (PAS-25-190) is a discretionary grant program that invites applications for R01 awards supporting independent, investigator-driven research projects that align with the scientific missions of participating NIH Institutes and Centers. The central purpose is to strengthen and diversify the biomedical, behavioral, clinical, and health-related research workforce by providing research support to investigators who are early in their independent careers or who may be at risk of losing research independence, particularly investigators from diverse backgrounds and groups that are underrepresented in the health-related sciences. Clinical trials are optional under this announcement, meaning applicants may propose a study that includes a clinical trial or one that does not, as long as the project fits NIH mission priorities and R01 expectations.

The opportunity is specifically designed for New Investigators and "At-Risk" Investigators, with a clear emphasis on broadening participation among researchers from underrepresented groups, consistent with NIH-wide diversity interests referenced in NOT-OD-20-031. The announcement notes that investigators in certain NIH-defined categories (called categories A and B in the notice) are especially encouraged to coordinate with their institutions when applying, reflecting NIH's intent to remove barriers and increase successful applications from investigators who have historically faced structural disadvantages in research funding and career advancement.

Eligibility is broad and spans many types of organizations that can serve as applicant institutions for the proposed R01 research. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (outside of higher education); for-profit organizations other than small businesses; small businesses; and other entities. The announcement also explicitly highlights additional eligible applicant types that align with workforce diversity goals, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also recognizes faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations as eligible in the context described by the notice.

From an administrative standpoint, the sponsoring agency is the National Institutes of Health, and the activity category is Health. The opportunity lists CFDA numbers covering multiple NIH program areas (93.172, 93.213, 93.242, 93.286, 93.313, 93.846, 93.853, 93.866, 93.867), signaling that multiple NIH Institutes or Centers may participate and that funded projects can span a wide range of health-related scientific topics. The opportunity was created on 2024-11-21, and the original closing date is 2027-11-05. The listing does not specify an award ceiling or the expected number of awards in the provided source data, which typically means applicants should consult the full NIH notice and participating Institute/Center guidance to understand budget expectations, any Institute-specific limits, and likely award volumes.

Overall, this announcement is best understood as an R01 pathway aimed at helping promising investigators, particularly those from underrepresented backgrounds or those at a vulnerable career stage, secure the kind of substantial, multi-year NIH research support that can establish or sustain an independent research program, build a track record of productivity, and contribute to a more inclusive and representative scientific workforce.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172, 93.213, 93.242, 93.286, 93.313, 93.846, 93.853, 93.866, 93.867.
• This funding opportunity was created on 2024-11-21.
• Applicants must submit their applications by 2027-11-05.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAS 25 190

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