Opportunity Information: Apply for PAR 17 476
This funding opportunity, titled "Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed)" (PAR-17-476), is a National Institutes of Health (NIH) grant program designed to support basic, mechanistic research on how ENDS aerosols affect the body. The core focus is on understanding the biological and physiological effects of exposure to aerosols produced by electronic nicotine delivery systems, with an emphasis on how these exposures influence normal function as well as disease-related processes in human-relevant cells, tissues, and organs. The intent is not to fund clinical trials, but to fund foundational studies that clarify the underlying mechanisms of harm or alteration, such as cellular pathways, tissue-level responses, and organ-specific impacts that could help explain observed or suspected health outcomes associated with ENDS use.
The announcement uses the NIH R01 mechanism, which typically supports substantial, multi-year research projects with clearly defined aims and a strong scientific premise. The work supported under this program is positioned as basic research, meaning it is geared toward building fundamental knowledge rather than testing interventions in people. In practical terms, this can include laboratory and preclinical studies that investigate how ENDS aerosol constituents interact with biological systems, how exposure triggers inflammation or oxidative stress, how it may alter immune responses or barrier function, and how it could contribute to the development or worsening of disease states relevant to major organs and tissues. The description emphasizes relevance to human cells, tissues, and organs, which often points to experimental approaches like cell culture, organotypic models, tissue explants, and other translationally meaningful model systems that help bridge the gap between chemistry of aerosols and real biological effects.
From an administrative standpoint, the opportunity is categorized as discretionary funding and uses the grant funding instrument type. It is listed under multiple CFDA numbers (93.113, 93.121, 93.279, 93.396), reflecting the NIH’s organization across institutes and program areas that can align with tobacco regulatory science and health research. The opportunity record shows an original closing date of June 29, 2018, and a creation date of September 7, 2017. The listing does not provide an award ceiling or expected number of awards in the provided source text, which means applicants would normally need to consult the full NIH announcement and related institute guidance for budget expectations, project period norms, and any institute-specific considerations.
Eligibility is broad across U.S.-based organizations and spans government, education, nonprofit, and private-sector entities. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; and small businesses. The announcement also calls out additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. In other words, the program is set up to be accessible to a wide range of domestic institutions that have the capacity to conduct rigorous basic biomedical and public health-relevant mechanistic research.
At the same time, there are explicit restrictions related to foreign participation. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) institutions are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible. In addition, foreign components, as defined by the NIH Grants Policy Statement, are not allowed. This effectively confines the applicant organization and the proposed work to domestic settings and domestic organizational structures, limiting the ability to place substantive project components abroad.
Overall, the opportunity is aimed at strengthening the scientific foundation for understanding how ENDS aerosols affect biology at a mechanistic level. By supporting basic research on the interaction between ENDS aerosol exposures and human-relevant biological systems, the program is meant to generate evidence that can clarify potential pathways of harm, identify biological targets and biomarkers, and improve the broader scientific understanding of how vaping-related exposures may influence health and disease processes, without involving clinical trial activity.Apply for PAR 17 476
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.279, 93.396.
- This funding opportunity was created on 2017-09-07.
- Applicants must submit their applications by 2018-06-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R21 - Clinical Trial Not Allowed) Apply for PAR 17 475 Funding Number: PAR 17 475 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Collaborative Minority Health and Health Disparities Research with Tribal Epidemiology Centers (R01) Apply for PAR 17 484 Funding Number: PAR 17 484 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $350,000 |
| Collaborative Minority Health and Health Disparities Research with Tribal Epidemiology Centers (R21) Apply for PAR 17 483 Funding Number: PAR 17 483 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Research to Improve Native American Health (R21 Clinical Trial Optional) Apply for PAR 17 464 Funding Number: PAR 17 464 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Intervention Research to Improve Native American Health (R01 Clinical Trial Optional) Apply for PAR 17 496 Funding Number: PAR 17 496 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Addressing Health Disparities through Effective Interventions Among Immigrant Populations (R01 Clinical Trial Optional) Apply for PA 18 284 Funding Number: PA 18 284 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Addressing Health Disparities through Effective Interventions Among Immigrant Populations (R21 Clinical Trial Optional) Apply for PA 18 285 Funding Number: PA 18 285 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| NIH Research Project Grant (Parent R01 Clinical Trial Required) Apply for PA 18 345 Funding Number: PA 18 345 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) Apply for PA 18 260 Funding Number: PA 18 260 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required) Apply for PA 18 344 Funding Number: PA 18 344 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Environmental Exposures and Health: Exploration of Non-Traditional Settings (R21 Clinical Trial Optional) Apply for PA 18 160 Funding Number: PA 18 160 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Environmental Exposures and Health: Exploration of Non-Traditional Settings (R01 Clinical Trial Optional) Apply for PA 18 142 Funding Number: PA 18 142 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trials Not Allowed) Apply for PA 18 371 Funding Number: PA 18 371 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - No Independent Clinical Trials) Apply for PA 18 394 Funding Number: PA 18 394 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program ( Parent R21 Clinical Trial Not Allowed) Apply for PA 18 489 Funding Number: PA 18 489 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 18 672 Funding Number: PA 18 672 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Not Allowed) Apply for PAR 18 704 Funding Number: PAR 18 704 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R21 Clinical Trial Not Allowed) Apply for PAR 18 703 Funding Number: PAR 18 703 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed) Apply for PAR 18 845 Funding Number: PAR 18 845 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R21 - Clinical Trial Not Allowed) Apply for PAR 18 846 Funding Number: PAR 18 846 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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