Opportunity Information: Apply for PA 18 480
The NICHD Research Project Grant (R01 - Clinical Trial Required) is a discretionary NIH funding opportunity (Funding Opportunity Number: PA 18 480; CFDA: 93.865) administered by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. It uses the R01 research project grant mechanism to support investigator-driven clinical trials that align with NICHDs mission areas, which broadly include research to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize the abilities of individuals through rehabilitation and related health research. The key feature of this particular announcement is that it is specifically intended for applications that include a clinical trial, meaning the proposed work must involve prospectively assigning human participants to one or more interventions to evaluate effects on health-related biomedical or behavioral outcomes, consistent with NIH definitions.
This opportunity is open to a wide range of applicant organizations across the public, private, nonprofit, and academic sectors. Eligible applicants include state, county, city or township, and special district governments, as well as independent school districts and public housing authorities (including Indian housing authorities). Higher education applicants may be public/state-controlled or private institutions of higher education. The program also allows applications from nonprofit organizations, whether they hold 501(c)(3) status or not (so long as they are not institutions of higher education), and it includes for-profit organizations other than small businesses, in addition to small businesses themselves. Tribal eligibility is broad: federally recognized Native American tribal governments are eligible, and Native American tribal organizations that are not federally recognized are also included. Beyond these categories, the announcement explicitly names additional eligible entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI). Faith-based and community-based organizations may apply, and the opportunity also extends to eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations), reflecting a willingness to support research teams and trial settings that best fit the scientific and public health need.
From an administrative standpoint, the opportunity is categorized under Health, Income Security and Social Services and is offered as a grant funding instrument. The source data indicates an original closing date of 2021-05-07 and a creation date of 2017-12-06. No award ceiling or expected number of awards is specified in the provided record, which is common for many NIH announcements where award size and volume depend on application quality, programmatic priorities, and available appropriations rather than a fixed cap stated in the synopsis.
In practical terms, this announcement is meant for applicants proposing rigorous, well-justified clinical trials under the traditional R01 structure, where the research question, design, participant protections, feasibility, and analytic plan are all central to the evaluation. Because it is an NICHD opportunity, competitiveness typically depends on how directly the clinical trial addresses NICHD-relevant health issues and populations, how sound and ethical the trial design is, and whether the investigative team and environment can realistically execute the study and generate results that matter for clinical care, public health practice, or future research.Apply for PA 18 480
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "NICHD Research Project Grant (R01 - Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2017-12-06.
- Applicants must submit their applications by 2021-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NICHD Research Project Grant (R01 - Clinical Trial Required) (PA 18 480)
What is this funding opportunity?
This is a discretionary NIH funding opportunity administered by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). It supports investigator-driven research projects using the R01 mechanism, and it is specifically intended for applications that include a clinical trial.
What is the official program name and identifier?
The opportunity is titled "NICHD Research Project Grant (R01 - Clinical Trial Required)." The Funding Opportunity Number (FON) is PA 18 480, and the CFDA number listed is 93.865.
Which NIH institute runs this program?
The program is administered by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What grant mechanism does this use?
It uses the NIH R01 research project grant mechanism.
Is a clinical trial required under this announcement?
Yes. A defining feature of this announcement is that the application must include a clinical trial.
How does this announcement define a clinical trial?
The proposed work must involve prospectively assigning human participants to one or more interventions to evaluate effects on health-related biomedical or behavioral outcomes, consistent with NIH definitions.
What kinds of research topics are a fit for NICHD?
Projects should align with NICHD mission areas, which broadly include research to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize the abilities of individuals through rehabilitation and related health research.
What type of funding instrument is offered?
The opportunity is offered as a grant.
What broad category is this opportunity listed under?
From an administrative standpoint, it is categorized under Health, Income Security and Social Services.
Who can apply for this grant?
The opportunity is open to a wide range of applicant organizations across public, private, nonprofit, and academic sectors, including domestic and non-U.S. entities (foreign organizations).
Are state and local governments eligible to apply?
Yes. Eligible applicants include state governments, county governments, city or township governments, and special district governments.
Can public housing authorities apply?
Yes. Public housing authorities are eligible, including Indian housing authorities.
Are independent school districts eligible?
Yes. Independent school districts are included among eligible applicants.
Are colleges and universities eligible?
Yes. Higher education applicants may be public/state-controlled institutions of higher education or private institutions of higher education.
Can nonprofit organizations apply?
Yes. Nonprofit organizations may apply whether they hold 501(c)(3) status or not, as long as they are not institutions of higher education.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also eligible.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and Native American tribal organizations that are not federally recognized are also included.
Are certain minority-serving institutions specifically named as eligible?
Yes. The announcement explicitly names Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Can faith-based or community-based organizations apply?
Yes. Faith-based and community-based organizations may apply.
Are federal agencies eligible to apply?
Yes. The opportunity extends to eligible federal agencies.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among eligible entities.
Are non-U.S. (foreign) organizations eligible?
Yes. Non-U.S. entities (foreign organizations) are explicitly included.
Is there a stated maximum award amount (award ceiling)?
No award ceiling is specified in the provided record.
Is there a stated expected number of awards?
No expected number of awards is specified in the provided record.
Why might award size or number of awards not be listed?
The provided information notes that this is common for many NIH announcements, where award size and volume can depend on application quality, programmatic priorities, and available appropriations rather than a fixed cap stated in the synopsis.
What makes an application competitive under this opportunity?
Competitiveness typically depends on how directly the proposed clinical trial addresses NICHD-relevant health issues and populations, how sound and ethical the trial design is, and whether the investigative team and environment can realistically execute the study and generate results that matter for clinical care, public health practice, or future research.
What kinds of study elements are emphasized for review, based on this description?
The description highlights the importance of a rigorous and well-justified clinical trial under the traditional R01 structure, with particular attention to the research question, design, participant protections, feasibility, and analytic plan.
What is the funding opportunity number (FON) for reference?
The Funding Opportunity Number is PA 18 480.
What is the CFDA number listed for this opportunity?
The CFDA number provided is 93.865.
What are the dates shown in the source record?
The source data indicates a creation date of 2017-12-06 and an original closing date of 2021-05-07.
Does the provided record indicate whether the opportunity is currently open?
The information provided includes an original closing date of 2021-05-07, but it does not provide any additional status details beyond that.
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| Studies in Neonatal and Pediatric Resuscitation (R03 - Clinical Trial Optional) Apply for PA 18 491 Funding Number: PA 18 491 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Non-Invasive Diagnostics to Improve Gynecologic Health (R43/R44 - Clinical Trial Optional) Apply for RFA HD 19 006 Funding Number: RFA HD 19 006 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Drug Repurposing for Conditions Affecting Neonates and Pregnant Women (R01 - Clinical Trial Optional) Apply for PAR 18 506 Funding Number: PAR 18 506 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery of Molecular Targets for Pregnancy-Related/Induced Diseases and Development of Therapeutics to Prevent/Treat These Diseases (R01 - Clinical Trial Optional) Apply for PAR 18 511 Funding Number: PAR 18 511 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Human-Animal Interaction (HAI) Research (R21 - Clinical Trial Optional) Apply for PAR 18 650 Funding Number: PAR 18 650 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Human-Animal Interaction (HAI) Research (R03 - Clinical Trial Optional) Apply for PAR 18 649 Funding Number: PAR 18 649 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Developmental Pharmacodynamics and Models of Drug Effects in Pediatrics (R03 Clinical Trial Optional) Apply for PA 18 687 Funding Number: PA 18 687 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Innovative Therapies and Tools for Screenable Disorders (R01 Clinical Trial Optional) Apply for PAR 18 689 Funding Number: PAR 18 689 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Innovative Therapies and Tools for Screenable Disorders (R03 Clinical Trial Optional) Apply for PAR 18 690 Funding Number: PAR 18 690 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Innovative Therapies and Tools for Screenable Disorders (R21 Clinical Trial Optional) Apply for PAR 18 691 Funding Number: PAR 18 691 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Developmental Pharmacodynamics and Models of Drug Effects in Pediatrics (R01 Clinical Trial Optional) Apply for PA 18 688 Funding Number: PA 18 688 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Reproductive Scientist Development Program (RSDP) (K12 Clinical Trial Not Allowed) Apply for RFA HD 18 103 Funding Number: RFA HD 18 103 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $920,000 |
| Small Research Grants for Establishing Basic Science-Clinical Collaborations to Understand Structural Birth Defects (R03 - Clinical Trial Not Allowed) Apply for PAR 18 734 Funding Number: PAR 18 734 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $75,000 |
| Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed) Apply for PAR 18 733 Funding Number: PAR 18 733 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Identification and Management of Behavioral Symptoms and Mental Health Conditions in Individuals with Intellectual Disabilities (R01 - Clinical Trial Optional) Apply for PAR 18 766 Funding Number: PAR 18 766 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R01 - Clinical Trial Optional) Apply for PA 18 790 Funding Number: PA 18 790 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R03 - Clinical Trial Optional) Apply for PA 18 791 Funding Number: PA 18 791 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
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