Opportunity Information: Apply for W81XWH 19 MRP TSA
The Department of Defense, through the U.S. Army Medical Research Acquisition Activity (USAMRAA), offered the FY19 Melanoma Research Program (MRP) Team Science Award (TSA) to fund hypothesis-driven melanoma studies that directly respond to the program's overarching FY19 MRP Challenge Statement and align with at least one required FY19 MRP Focus Area. The core purpose of this opportunity is to push melanoma research forward by requiring a true multidisciplinary team approach, where investigators from different fields combine their expertise to create a single, integrated research project that would not be achievable through separate, independent efforts. In other words, the emphasis is not just on collaboration in name, but on a clearly defined scientific synergy that accelerates progress by merging distinct perspectives, methods, and skill sets.
A defining feature of the TSA mechanism is its team structure and application format. The investigators must jointly design one shared project, but each partnering investigator is treated as a Principal Investigator (PI) and must submit a separate application. Each PI would be the named PI on their own individual award, even though the science is intended to function as one coordinated project. For applicants, this means the proposal needs to spell out how the work is divided and integrated across the team, what each PI uniquely contributes, and how the combined approach fills critical knowledge gaps in melanoma. Reviewers would be looking for evidence that the team composition is intentional and complementary, not redundant, and that the project's success depends on the interaction among disciplines.
The scope is broad across the melanoma research spectrum so long as the work is hypothesis-driven and tied to the FY19 MRP Challenge Statement and Focus Areas. The program allows research that uses animal models, human subjects, and human anatomical substances, and it also allows the development or use of relevant preclinical models when that is necessary to accomplish the aims. At the same time, several boundaries are clearly stated. The TSA is not meant to support research centered on established late-stage disease models, and it is not intended to evaluate the clinical utility of PD-1 in combination with other therapeutics. Projects involving non-melanoma skin cancers are explicitly prohibited under this program. Clinical trials are not allowed, which places the work primarily in basic, translational, and preclinical domains rather than interventional clinical testing.
The opportunity also limits certain technology-heavy approaches when they are the primary thrust of the work. It states that the TSA is not intended to support high-throughput screenings or large-scale sequencing efforts as the main activity. This does not necessarily mean such methods could never appear as supporting tools, but it signals that the program is prioritizing focused, hypothesis-driven mechanistic or translational studies over discovery efforts dominated by broad, untargeted "omics" or screening pipelines.
Administratively, this opportunity was listed as a discretionary funding opportunity under the Department of Defense (Department of the Army, USAMRAA), with funding instruments including grants and cooperative agreements. It carried the funding opportunity number W81XWH-19-MRP-TSA and CFDA 12.420. Eligibility was described as unrestricted (open to any type of entity), subject to any additional eligibility clarifications in the full announcement. The posting date was May 16, 2019, with an original closing date of October 23, 2019. The notice anticipated approximately two awards, and the award ceiling was listed as 0 in the source data, which typically indicates that the maximum funding level was not specified in that particular summary field and would need to be confirmed in the full program announcement or related budget guidance.Apply for W81XWH 19 MRP TSA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Melanoma, Team Science Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on May 16, 2019.
- Applicants must submit their applications by Oct 23, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQ)
What is the FY19 Melanoma Research Program (MRP) Team Science Award (TSA)?
The FY19 MRP Team Science Award (TSA) is a Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It supports hypothesis-driven melanoma research that directly responds to the FY19 MRP Challenge Statement and aligns with at least one required FY19 MRP Focus Area. The defining expectation is a true multidisciplinary team project designed as one integrated effort.
What is the main purpose of the Team Science Award?
The core purpose is to accelerate progress in melanoma research by requiring a genuine multidisciplinary approach. The program emphasizes scientific synergy, meaning the work should rely on the interaction of distinct disciplines and combined expertise to achieve outcomes that would not be achievable through separate, independent projects.
What does "team science" mean for this program?
In this opportunity, "team science" means the investigators jointly design a single, coordinated research project with a clearly integrated plan. The collaboration must be more than nominal. The project should show how different perspectives, methods, and skill sets combine in a complementary way to address critical knowledge gaps in melanoma.
How is the research project structured under the TSA?
The team must create one shared scientific project. However, each partnering investigator is treated as a Principal Investigator (PI) and must submit a separate application. Each PI is the named PI on their own individual award, even though the research is intended to function as one coordinated project.
Do all partnering investigators need to submit separate applications?
Yes. Each partnering investigator (each PI) must submit a separate application, and each PI would be the named PI on their own individual award. The overall science should still read as a single integrated team project.
What do reviewers expect to see regarding team roles and integration?
Based on the program description, reviewers would look for a clear explanation of how the work is divided across the team and how it is integrated into one project. They would also expect each PI's unique contribution to be well-defined, and the team composition to be complementary and non-redundant. The application should demonstrate that success depends on cross-disciplinary interaction.
What types of research are in scope?
The scope is broad across the melanoma research spectrum as long as the project is hypothesis-driven and tied to the FY19 MRP Challenge Statement and Focus Areas. The program allows research involving animal models, human subjects, and human anatomical substances. It also allows the development or use of relevant preclinical models when needed to accomplish the aims.
Are studies using animal models allowed?
Yes. The program description states that research using animal models is allowed, as long as it is hypothesis-driven and aligned with the FY19 MRP Challenge Statement and at least one required Focus Area.
Are human subjects or human anatomical substances allowed?
Yes. The program allows research that uses human subjects and human anatomical substances, provided the work fits the stated scope and restrictions.
Are clinical trials allowed under this opportunity?
No. Clinical trials are explicitly not allowed under this Team Science Award, indicating that the supported work is intended to remain in basic, translational, and preclinical domains rather than interventional clinical testing.
Are projects involving non-melanoma skin cancers eligible?
No. Projects involving non-melanoma skin cancers are explicitly prohibited under this program.
Is research focused on established late-stage disease models supported?
No. The TSA is not meant to support research centered on established late-stage disease models.
Can a project evaluate the clinical utility of PD-1 in combination with other therapeutics?
No. The opportunity states it is not intended to evaluate the clinical utility of PD-1 in combination with other therapeutics.
Are high-throughput screenings or large-scale sequencing efforts allowed?
The program states the TSA is not intended to support high-throughput screenings or large-scale sequencing efforts as the main activity. This suggests such approaches should not be the primary thrust of the project, even if they may appear as supporting tools in a hypothesis-driven study.
Who is the sponsoring agency for this opportunity?
The opportunity is offered by the Department of Defense, through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA).
What funding instruments are associated with this opportunity?
The funding instruments listed for this opportunity include grants and cooperative agreements.
What is the funding opportunity number (FON)?
The funding opportunity number is W81XWH-19-MRP-TSA.
What is the CFDA number for this program?
The CFDA number listed is 12.420.
Who is eligible to apply?
Eligibility was described as unrestricted (open to any type of entity), subject to any additional eligibility clarifications in the full announcement.
When was the opportunity posted and when did it close?
The posting date was May 16, 2019. The original closing date was October 23, 2019.
How many awards were expected to be made?
The notice anticipated approximately two awards.
What was the maximum award amount (award ceiling)?
The award ceiling was listed as 0 in the source data. In this context, that typically indicates the maximum funding level was not specified in that summary field and would need to be confirmed in the full program announcement or related budget guidance.
Is this a discretionary funding opportunity?
Yes. It was listed as a discretionary funding opportunity under the Department of Defense (Department of the Army, USAMRAA).
What is the key compliance theme applicants should keep in mind from the description?
The key theme is alignment and fit: the project must be hypothesis-driven, directly respond to the FY19 MRP Challenge Statement, align with at least one required Focus Area, and meet the specific boundaries (no clinical trials, no non-melanoma skin cancers, not centered on established late-stage disease models, not focused on PD-1 combination clinical utility, and not primarily high-throughput screening or large-scale sequencing).
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