Opportunity Information: Apply for PAR 19 156
The Bioengineering Research Partnerships (U01 Clinical Trial Not Allowed) funding opportunity (PAR-19-156) is a National Institutes of Health (NIH) cooperative agreement program designed to speed up the development and real-world adoption of high-impact bioengineering tools and technologies that address important biomedical problems. The central idea is not just to invent something novel, but to turn a promising concept into a robust, well-characterized solution that clearly fills an unmet need and can be broadly used to deepen understanding of biological processes or improve the practice of medicine. The program is framed around translational bioengineering progress, meaning applicants are expected to move beyond early proof-of-concept work and instead build technology that others can reliably use, reproduce, and trust.
A defining feature of this FOA is its emphasis on multidisciplinary, team-based research partnerships. Projects are expected to bring together engineers and quantitative scientists with biomedical researchers and/or clinicians in a tightly integrated way, with the biomedical or clinical perspective involved throughout the full lifecycle of the project rather than being added late as an end user. NIH is looking for integrative and quantitative bioengineering approaches, which typically implies strong grounding in measurement, modeling, performance validation, and iterative optimization under realistic biological or clinical constraints. The intended outcome is technology that is not only innovative, but engineered to be practical: well specified, benchmarked, and positioned for adoption by the broader research or medical community.
The program’s time horizon is also explicit. The stated goal is to support projects that can deliver meaningful solutions within roughly 5 to 10 years, which signals a preference for development plans with credible milestones, clear validation pathways, and a realistic strategy for maturing the technology into something that can become a standard tool, platform, or enabling capability. While the FOA supports development, it is not intended for clinical trials, as indicated by the designation "Clinical Trial Not Allowed." In other words, applicants should propose preclinical, methodological, technological, or enabling research and development that prepares a technology for eventual use, without conducting a clinical trial as part of the funded scope.
From an administrative standpoint, this opportunity is categorized as a discretionary grant using a cooperative agreement mechanism (U01). A cooperative agreement typically means NIH program staff will have substantial involvement during the project compared with a standard research grant, often through active coordination, shared governance expectations, or involvement in steering and oversight activities. The funding activity category is listed under environment and health, and the associated CFDA (assistance listing) numbers include 93.113, 93.273, 93.286, and 93.866, reflecting that multiple NIH institutes or program areas may participate or align with the scope depending on the specific scientific focus.
Eligibility is broad and intentionally inclusive across many institution types and sectors. Eligible applicants include state, county, city, township, and special district governments, as well as independent school districts and public housing authorities/Indian housing authorities. Academic eligibility spans public and state-controlled institutions of higher education, private institutions of higher education, and a wide range of minority-serving and special-designation institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Tribal entities are eligible in several forms, including federally recognized Native American tribal governments and other Native American tribal organizations, as well as Indian/Native American tribal governments that are not federally recognized. The FOA also allows participation from nonprofit organizations both with and without 501(c)(3) status (outside of higher education institutions), for-profit organizations (other than small businesses), and small businesses. Additional eligible applicant categories explicitly mentioned include eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities (foreign organizations), expanding the potential for international collaboration when appropriate.
Key logistical details from the listing include the NIH as the sponsoring agency, an original closing date of January 7, 2022, and a creation date of January 8, 2019. The public summary does not specify an award ceiling or the expected number of awards, suggesting applicants would need to consult the full FOA text and related NIH institute guidance for budget expectations, project period limits, and programmatic priorities. Overall, the opportunity is geared toward teams that can convincingly demonstrate a path from bioengineering innovation to widely adopted, rigorously validated tools or technologies that materially advance biomedical research or medical practice, without conducting clinical trials within the proposed work.Apply for PAR 19 156
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Bioengineering Research Partnerships (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.273, 93.286, 93.866.
- This funding opportunity was created on 2019-01-08.
- Applicants must submit their applications by 2022-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Innovative Approaches for Improving Environmental Health Literacy (R41/R42 Clinical Trial Not Allowed) Apply for RFA ES 19 006 Funding Number: RFA ES 19 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Innovative Approaches for Improving Environmental Health Literacy (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 19 005 Funding Number: RFA ES 19 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Award (K01 Independent Basic Experimental Studies with Humans Required) Apply for PAR 19 225 Funding Number: PAR 19 225 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Clinical Trial Not Allowed) Apply for RFA ES 19 007 Funding Number: RFA ES 19 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Basic Experimental Studies with Humans Required) Apply for RFA ES 19 008 Funding Number: RFA ES 19 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed) Apply for PAR 19 249 Funding Number: PAR 19 249 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 19 009 Funding Number: RFA ES 19 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25 Clinical Trial Not Allowed) Apply for RFA ES 19 010 Funding Number: RFA ES 19 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| HAZMAT Training at DOE Nuclear Weapons Complex (UH4 Clinical Trial Not Allowed) Apply for RFA ES 19 004 Funding Number: RFA ES 19 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Hazardous Materials Worker Health and Safety Training (U45 Clinical Trial Not Allowed) Apply for RFA ES 19 003 Funding Number: RFA ES 19 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Pregnancy as a Vulnerable Time Period for Women's Health (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 003 Funding Number: RFA ES 20 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $300,000 |
| Limited Competition: Specialized Centers of Excellence on Environmental Health Disparities Research (P50) Apply for RFA MD 20 001 Funding Number: RFA MD 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $950,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R01 Clinical Trial Not Allowed) Apply for PAR 19 386 Funding Number: PAR 19 386 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R21 Clinical Trial Not Allowed) Apply for PAR 19 385 Funding Number: PAR 19 385 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 005 Funding Number: RFA ES 20 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) Apply for RFA ES 20 002 Funding Number: RFA ES 20 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional) Apply for RFA ES 20 006 Funding Number: RFA ES 20 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional) Apply for RFA ES 20 009 Funding Number: RFA ES 20 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| U.S. - India Collaborative Environmental Health Research Program (R01 Clinical Trial Optional) Apply for RFA ES 20 010 Funding Number: RFA ES 20 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 012 Funding Number: RFA ES 20 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
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